Gene: [02^/LTBP1] latent transforming growth factor beta binding protein 1;
FUN | LTBP1 is covalently bound to extracellular matrix and thus mediates the matrix binding of TGF-beta (GEM:19q131/TGFB1)." |
MOP | The structure of human LTBP1 resembles fibrillin (GEM:15q211/FBN1) in that it includes 16 epidermal growth factor-like repeats and 3 copies of a novel 8-cysteine motif. LTBP purified from different tissues may have different sizes owing to either proteolytic cleavage or alternative splicing." |
FAG | The following LTBP genes are currently identified: GEM:02^/LTBP1; GEM:14q24/LTBP2; GEM:11q12/LTBP3." |
REF | CLO,SEQ,EXP "Kanzaki T
&: Cell, 61, 1051-1061, 1990 CLO,LOC "Stenman G &: CCG, 66, 117-119, 1994 |
SWI | SWISSPROT: P22064 |
KEY | exce, cyk |
CLA | coding, basic |
LOC | 02 p12-q22 |
MIM | MIM: 150390 |
